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Clinical Studies

Onnit is committed to demonstrating that supplements containing earth grown nutrients can improve human performance. With every ingredient we choose, we analyze all the scientific data to ensure we are creating the absolute safest and best formulations in the world.

Then we take it a step further. By testing our flagship formulas through rigorous clinical trial analysis with top academic institutions we seek to ensure that our formulas represent the pinnacle of human optimization. So far, we have had three successful trials in three attempts, the details of which are below.

Clinical Trials

A Proof of Concept for a Randomized, Double Blind, Placebo Controlled, Parallel Group, Efficacy Study of Alpha Brain™ Administered Orally

Solomon et al. International Neuropsychological Society Meeting, 2014

Significant Findings:

  • The first study to show improvements in verbal memory and executive function with Alpha BRAIN supplementation†

A Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Efficacy Study of Alpha BRAIN Administered Orally

Solomon et al. The Journal of Human Psychopharmacology: Clinical and Experimental. 2015 Conducted through a collaboration between the Boston Center for Memory, Boston University School of Medicine, and Williams College.

Significant Findings:

  • 12% greater improvement in verbal recall over placebo
  • 21% faster completion time in executive function assessment compared to baseline
  • Replicated results observed in the initial pilot study
  • Equally as safe and tolerable as placebo
Chart showing words recalled from memory with Alpha BRAIN vs. placebo

Effects of the Nootropic Compound Alpha BRAIN on ERP and EEG Measures of Cognitive Performance†

Leech et al. Alzheimer’s Association International Conference, June 2015

Significant Findings:

  • A single dose of Alpha BRAIN resulted in 26 millisecond faster processing speed time in detecting the target stimuli compared to a single dose of placebo†
  • Alpha BRAIN enhanced target discrimination with higher amplitude detection waves in the frontal lobes of the brain†
  • Resting EEG recordings showed Alpha BRAIN increased the peak alpha frequency, known to reflect a state of focus†
Charts showing theta/beta ratio and peak alpha for Alpha BRAIN vs. placebo

Research

Impact of Four Weeks of a Multi-Ingredient Performance Supplement on Muscular Strength, Body Composition, and Anabolic Hormones in Resistance-Trained Young Men

Kreipke et al., Journal of Strength and Conditioning Research, 2015

A double-blind efficacy study of Total Strength+Performance, conducted by Florida State University, randomized 27 college-aged powerlifters to Total Strength+Performance or placebo supplementation.

Significant Findings:

  • Total Strength+Performance significantly increased improvement in 1 rep max for squat, bench and deadlift combined total weight compared to placebo†
  • Four weeks of training with Total Strength+Performance added an average 6 kilograms (13.7 lbs) to 1RM bench press
  • Total Strength+Performance was well tolerated and did not alter hormone profiles

Onnit continues to aim research towards pushing the boundaries of human performance. Our studies include individuals who represent a demographic consistent with the athletes and customers that rely on Onnit products.

After selecting the highest level academic research centers to conduct our studies, the data is subjected to the rigorous peer-review process at nationwide conferences and through publication in scientific journals.

These publications continue to attract attention from health professionals and are leading to the initiation of new, innovative research trials.


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